Experimenting is normally relegated to others as they have no time to test uncertain tasks when the old ways work fine for them. However, if something promises to promote quicker finishing or better results they may then opt to change to that for awhile.
These are also the guys that love to use complex mathematical formulas to produce their colors, such as the Munsell system. Often times craftsmen could probably better be called scientists of art.
Toxicity is not an issue with the craftsmen so long as it does not interfere with their work. Often times toxic materials are used for their better working qualities. A good example being lead white. If the craftsmen will speak with you, or better yet, teach you, there is much to learn from them.
I’ve learned the most from those that work mostly in this manner, while I don’t really condone the use of mathematical formulas to mix all my paint, I do like its results. These people know what they’re doing, seek them out.